Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT

Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity.This migration is controlled by CXCL12/CXCR4-mediated activation of the protein Shirts kinase AKT.Herein, we show that the CXCL12-induced migration of human plasmablasts is dependent on glucose o

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Modern view on hemostasis system: cell theory

For many years, there has been no model capable of explaining the complex processes of interaction between various bloodclotting factors leading to a stop of bleeding.One of the most successful models Glycine able to partially reflect the mechanisms of hemostasis for a long time was the cascade theory.The cascade model perfectly explains the proces

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Identidad y política en el nuevo movimiento mapuche

La relación entre el Estado chileno y el pueblo mapuche es determinada por el poder, y es precisamente dicho poder – detentado por el Estado y toda STOMACH EASE su institucionalidad – el que da forma a una relación histórica asimétrica caracterizada por la dominación y la resistencia: dos caras de la misma moneda.En las últimas tres déca

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