Elevated bone marrow adiposity is defined as an increase in the proportion of the bone marrow cavity volume occupied by adipocytes.This can be caused by an increase in the size and/or number of adipocytes.Bone marrow adiposity increases Gift Card with age in a bone-site-specific manner.This increase may be linked to certain pathophysiological situa
Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT
Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity.This migration is controlled by CXCL12/CXCR4-mediated activation of the protein Shirts kinase AKT.Herein, we show that the CXCL12-induced migration of human plasmablasts is dependent on glucose o
Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus
ABSTRACTMycobacterium abscessus is a non-tuberculous mycobacterium, causing lung infections in cystic fibrosis patients.During pulmonary infection, M.abscessus switches from smooth (Mabs-S) to rough (Mabs-R) morphotypes, the latter being hyper-virulent.Previously, we isolated the lsr2 gene as differentially expressed during S-to-R transition.lsr2 e
Modern view on hemostasis system: cell theory
For many years, there has been no model capable of explaining the complex processes of interaction between various bloodclotting factors leading to a stop of bleeding.One of the most successful models Glycine able to partially reflect the mechanisms of hemostasis for a long time was the cascade theory.The cascade model perfectly explains the proces
Identidad y política en el nuevo movimiento mapuche
La relación entre el Estado chileno y el pueblo mapuche es determinada por el poder, y es precisamente dicho poder – detentado por el Estado y toda STOMACH EASE su institucionalidad – el que da forma a una relación histórica asimétrica caracterizada por la dominación y la resistencia: dos caras de la misma moneda.En las últimas tres déca